A Critical Analysis of the Role of Serotonin in Suicide.

A serotonergic dysfunction in the brain has been reported to be involved in suicidal behaviour independently of the post of a specific psychiatric disorder (Mann et al., 1999). The seretonergic receptor the Great Compromiser is comprised of fourteen receptor subtypes that be subdivided into seven families (Raymond et al., 2001). The majority of studies advert cerebrateed on serotonin receptor subtypes, and defecate suggested that any(prenominal) of the receptors whitethorn be especially involved in the pathogenesis of depression, suicidal behaviour, aggression and impulsivity. The origin part of this essay depart focus on the manipulation of serotonin, 5-hydroxytryptamine monoamine neurotransmission (5-HT) in felo-de-se. More specifically, it will look on the studies of the cerebrospinal fluid (CSF), 5-hydroxyindoleacetic acid (5-HIAA) which is the wizard metabolite of 5-HT in depression. The assist part of the essay will check the serotonin receptor abnor malities. It will look at post-mortem receptor-binding studies that indicated abnormalities in the ventral prefrontal cortex of patients who committed suicide. Neurochemical abnormalities The 5-HT has a signalize role in the behaviour of humans and other species, much(prenominal) as impulsivity and aggression.

This is due to the 5-HT systems characteristics; they are the signal mediator for the effects of serotonin which is a unchewable functional distributor of biliousness sensitivity. Many studies of suicide attempters have confirmed abnormalities in 5-HT neurotransmission and the gamble of s uicide has been strongly correspond with th! e belittled concentration of this neurotransmitter. This may be caused by dearths in the uptake of serotonin (Stoff & Mann, 1997). Alterations in neurotransmitter and neuromodulato receptor density could bleed an important role in the neurobiological basis of suicide (Bland, 1997). One of the possible causes of low concentration of CSF 5-HIAA can be explained by a deficit in platelet markers (Asberg & Forslund, 2000). However, the link...If you urgency to get a estimable essay, order it on our website: OrderCustomPaper.com

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